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AboutPricing
Drug ReportsInsulin detemir
Levemir(insulin detemir)
Levemir (insulin detemir) is a protein pharmaceutical. Insulin detemir was first approved as Levemir on 2004-06-01. It has been approved in Europe to treat diabetes mellitus.
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Drug
Target
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Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
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Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nutritional and metabolic diseasesD009750
endocrine system diseasesD004700
Trade Name
FDA
EMA
Levemir (discontinued: Levemir)
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Insulin detemir
Tradename
Proper name
Company
Number
Date
Products
Levemirinsulin detemirNovo NordiskN-21536 RX2005-06-16
2 products
Show 1 discontinued
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A10: Drugs used in diabetes
— A10A: Insulins and analogues
— A10AE: Insulins and analogues for injection, long-acting
— A10AE05: Insulin detemir
HCPCS
No data
Clinical
Clinical Trials
230 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetes mellitusD003920EFO_0000400E08-E13162524976195
Type 2 diabetes mellitusD003924EFO_0001360E1142264164137
Type 1 diabetes mellitusD003922EFO_0001359E107130113079
Gestational diabetesD016640—O24.4—11237
HyperglycemiaD006943—R73.9—1—4—5
OverweightD050177—E66.3——1214
ObesityD009765EFO_0001073E66.9——1124
Weight gainD015430————11—2
Cardiovascular diseasesD002318EFO_0000319I98——11—2
AtherosclerosisD050197EFO_0003914I25.1——11—2
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
FibrosisD005355———23——3
Cystic fibrosisD003550EFO_0000390E84—23——3
HypertensionD006973EFO_0000537I10——1——1
HypercholesterolemiaD006937————1——1
Coronary diseaseD003327————1——1
Puerperal disordersD011644EFO_0009683O89——1——1
Prediabetic stateD011236EFO_1001121R73.03—11——1
Drug delivery systemsD016503————1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Alzheimer diseaseD000544EFO_0000249F03—2———2
Cognitive dysfunctionD060825—G31.84—2———2
Chronic obstructive pulmonary diseaseD029424EFO_0000341J44.9—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———6————6
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetes complicationsD048909——————22
Pregnancy rateD018873——————22
Insulin resistanceD007333EFO_0002614E88.819————11
KetosisD007662—R82.4————11
Diabetic ketoacidosisD016883EFO_1000897—————11
GastroparesisD018589EFO_1000948K31.84————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameInsulin detemir
INNinsulin detemir
Description
Insulin detemir, sold under the brand name Levemir among others, is a long-acting modified form of medical insulin used to treat both type 1 and type 2 diabetes. It is used by injection under the skin. It is effective for up to 24 hours.
Classification
Protein
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CSSC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N2)[C@@H](C)O)C(=O)O
Identifiers
PDB—
CAS-ID169148-63-4
RxCUI—
ChEMBL IDCHEMBL2104391
ChEBI ID—
PubChem CID—
DrugBankDB01307
UNII ID4FT78T86XV (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Levemir – Novo Nordisk
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Estimated US medical usage
Insulin detemir
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,837 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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15,011 adverse events reported
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